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Can I read COVID‐19: Histopathological correlates of imaging patterns on chest computed tomography on EtoBox?
COVID‐19: Histopathological correlates of imaging patterns on chest computed tomography by Azar Kianzad; Lilian J. Meijboom; Esther J. Nossent; Eva Roos; Bernadette Schurink; Peter I. Bonta; Inge A. H. van den Berk; Rieneke Britstra; Jaap Stoker; Anton Vonk Noordegraaf; Paul van der Valk; Erik Thunnissen; Marianna Bugiani; Harm Jan Bogaard; Teodora Radonic is a Medicine article available to read on EtoBox.
What is COVID‐19: Histopathological correlates of imaging patterns on chest computed tomography about?
## Abstract ## Background and objective Patients with coronavirus disease 2019 (COVID‐19) pneumonia present with typical findings on chest computed tomography (CT), but the underlying histopathological patterns are unknown. Through direct regional correlation of imaging findings to histopathological patterns, this study aimed to explain typical COVID‐19 CT patterns at tissue level. ## Methods Eight autopsy cases were prospectively selected of patients with PCR‐proven COVID‐19 pneumonia with varying clinical manifestations and causes of death. All had been subjected to chest CT imaging 24–72 h prior to death. Twenty‐seven lung areas with typical COVID‐19 patterns and two radiologically unaffected pulmonary areas were correlated to histopathological findings in the same lung regions. ## Results Two dominant radiological patterns were observed: ground‐glass opacity (GGO) (n = 11) and consolidation (n = 16). In seven of 11 sampled areas of GGO, diffuse alveolar damage (DAD) was observed. In four areas of GGO, the histological pattern was vascular damage and thrombosis, with (n = 2) or without DAD (n = 2). DAD was also observed in five of 16 samples derived from areas of radiological co
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- Author
- Azar Kianzad; Lilian J. Meijboom; Esther J. Nossent; Eva Roos; Bernadette Schurink; Peter I. Bonta; Inge A. H. van den Berk; Rieneke Britstra; Jaap Stoker; Anton Vonk Noordegraaf; Paul van der Valk; Erik Thunnissen; Marianna Bugiani; Harm Jan Bogaard; Teodora Radonic
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)