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Can I read In Vitro Efficacy of Brincidofovir against Variola Virus on EtoBox?
In Vitro Efficacy of Brincidofovir against Variola Virus by Victoria A. Olson; Scott K. Smith; Scott Foster; Yu Li; E. Randall Lanier; Irina Gates; Lawrence C. Trost; Inger K. Damon is a Medicine article available to read on EtoBox.
What is In Vitro Efficacy of Brincidofovir against Variola Virus about?
## ABSTRACT Brincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using “the Animal Rule,” established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models. Compared to cidofovir, brincidofovir has increased potency, is administered orally, and shows no evidence of nephrotoxicity. Here we report that the brincidofovir half-maximal effective concentration (EC ~50~ ) against five variola virus strains __in vitro__ averaged 0.11 μM and that brincidofovir was therefore nearly 100-fold more potent than cidofovir.
Who reads In Vitro Efficacy of Brincidofovir against Variola Virus?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Victoria A. Olson; Scott K. Smith; Scott Foster; Yu Li; E. Randall Lanier; Irina Gates; Lawrence C. Trost; Inger K. Damon
- Publisher
- American Society for Microbiology
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)