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Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval by Anghelus Ostroveanu; Eddy A. van der Zee; Ulrich L.M. Eisel; Martina Schmidt; Ingrid M. Nijholt is a Neuroscience article available to read on EtoBox.
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## Abstract Knowledge on the molecular mechanisms involved in memory retrieval is limited due to the lack of tools to study this stage of the memory process. Here we report that exchange proteins activated by cAMP (Epac) play a surprisingly specific role in memory retrieval. Intrahippocampal injection of the Epac activator 8‐pCPT‐2′O‐Me‐cAMP was shown to improve fear memory retrieval in contextual fear conditioning whereas acquisition and consolidation were not affected. The retrieval enhancing effect of the Epac activator was even more prominent in the passive avoidance paradigm. Down‐regulation of Epac2 expression in the hippocampal CA1 area impaired fear memory retrieval when the memory test was performed 72 h after training, but not when tested after 17 days. Our data thus identify an important time‐limited role for hippocampal Epac2 signaling in cognition and opens new avenues to investigate the molecular mechanisms underlying memory retrieval. © 2009 Wiley‐Liss, Inc.
Who reads Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Anghelus Ostroveanu; Eddy A. van der Zee; Ulrich L.M. Eisel; Martina Schmidt; Ingrid M. Nijholt
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)
- Published
- 2010
- Language
- EN
- Field
- Neuroscience (Life Sciences)