Can I read Simultaneous Determination of a Novel Calcium Entry Blocker, Monatepil Maleate, and Its Metabolites in Rat Plasma by Means of Solid-phase Extraction and Reversed-phase Liquid Chromatography with Electrochemical Detection on EtoBox?

Simultaneous Determination of a Novel Calcium Entry Blocker, Monatepil Maleate, and Its Metabolites in Rat Plasma by Means of Solid-phase Extraction and Reversed-phase Liquid Chromatography with Electrochemical Detection by Masuo Kurono; Kenji Suzuki; Koji Yoshida; Shunsuke Naruto is a Chemistry article available to read on EtoBox.

What is Simultaneous Determination of a Novel Calcium Entry Blocker, Monatepil Maleate, and Its Metabolites in Rat Plasma by Means of Solid-phase Extraction and Reversed-phase Liquid Chromatography with Electrochemical Detection about?

A reversed-phase LC method with electrochemical detection is described for the simultaneous determination of monatepil maleate (AJ-2615, AJ), a novel calcium entry blocker, and its three S-oxidized metabolites in plasma. These compounds were extracted from plasma by solid-phase extraction and injected onto an ODS column. The determination limit in plasma (0.5 ml) was 10 ng/ml for AJ and 5 ng/ml for the three metabolites. The method was applied to the determination of AJ and the metabolites in rat plasma samples.

Who reads Simultaneous Determination of a Novel Calcium Entry Blocker, Monatepil Maleate, and Its Metabolites in Rat Plasma by Means of Solid-phase Extraction and Reversed-phase Liquid Chromatography with Electrochemical Detection?

Author

Masuo Kurono; Kenji Suzuki; Koji Yoshida; Shunsuke Naruto

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)

Published

1997

Language

EN

Field

Chemistry (Physical Sciences)