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Can I read Cardiovascular Responses to Noradrenaline Microinjection in the Ventrolateral Periaqueductal Gray of Unanesthetized Rats on EtoBox?
Cardiovascular Responses to Noradrenaline Microinjection in the Ventrolateral Periaqueductal Gray of Unanesthetized Rats by Gislaine Garcia Pelosi; Rodrigo Fiacadori Tavares; José Antunes-Rodrigues; Fernando Morgan Aguiar Corrêa is a Neuroscience article available to read on EtoBox.
What is Cardiovascular Responses to Noradrenaline Microinjection in the Ventrolateral Periaqueductal Gray of Unanesthetized Rats about?
## Abstract The periaqueductal gray area (PAG) is a mesencephalic area involved in cardiovascular modulation. Noradrenaline (NA), a neurotransmitter involved in central blood pressure control, is present in the rat PAG. We report here on the cardiovascular effects caused by NA microinjection into the ventrolateral PAG (vlPAG) of unanesthetized rats and the peripheral mechanism involved in their mediation. NA microinjection in the vlPAG of unanesthetized rats evoked dose‐related pressor and bradycardiac responses. No significant cardiovascular responses were observed in urethane‐anesthetized rats. The pressor response was potentiated by pretreatment with the ganglion blocker pentolinium (5 or 10 mg/kg, intravenously). Pretreatment with the vasopressin antagonist dTyr(CH~2~)~5~ (Me)AVP (50 μg/kg, intravenously) blocked the pressor response evoked by the NA microinjection into the vlPAG. Additionally, circulating vasopressin content was found to be significantly increased after NA microinjection in the vlPAG. The results suggest that activation of noradrenergic synapses within the vlPAG modulates vasopressin release in unanesthetized rats. © 2007 Wiley‐Liss, Inc.
Who reads Cardiovascular Responses to Noradrenaline Microinjection in the Ventrolateral Periaqueductal Gray of Unanesthetized Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Gislaine Garcia Pelosi; Rodrigo Fiacadori Tavares; José Antunes-Rodrigues; Fernando Morgan Aguiar Corrêa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)