Can I read Exposure to a Maternal N-3 Fatty Acid-deficient Diet During Brain Development Provokes Excessive Hypothalamic–pituitary–adrenal Axis Responses to Stress and Behavioral Indices of Depression and Anxiety in Male Rat Offspring Later in Life on EtoBox?

Exposure to a Maternal N-3 Fatty Acid-deficient Diet During Brain Development Provokes Excessive Hypothalamic–pituitary–adrenal Axis Responses to Stress and Behavioral Indices of Depression and Anxiety in Male Rat Offspring Later in Life by Hui-Feng Chen; Hui-Min Su is a Medicine article available to read on EtoBox.

What is Exposure to a Maternal N-3 Fatty Acid-deficient Diet During Brain Development Provokes Excessive Hypothalamic–pituitary–adrenal Axis Responses to Stress and Behavioral Indices of Depression and Anxiety in Male Rat Offspring Later in Life about?

Brain docosahexaenoic acid (DHA, 22:6n-3) accumulates rapidly during brain development and is essential for normal neurological function. The aim of this study was to evaluate whether brain development was the critical period in which DHA deficiency leads to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress later in life. Rats were exposed to an n-3 fatty acid-deficient diet or the same diet supplemented with fish oil as an n-3 fatty acid-adequate diet either throughout the preweaning period from embryo to weaning at 3 weeks old or during the postweaning period from 3 to 10 weeks old. Exposure to the n-3 fatty acid-deficient diet during the preweaning period resulted, at weaning, in a significant decrease in hypothalamic DHA levels and a reduced male offspring body weight. DHA deficiency during the preweaning period significantly increased and prolonged restraint stress-induced changes in colonic temperature and serum corticosterone levels, caused a significant increase in GABA(A) antagonist-induced heart rate changes and enhanced depressive-like behavior in the forced swimming test and anxiety-like behavior in the plus-maze test in later life. Th

Who reads Exposure to a Maternal N-3 Fatty Acid-deficient Diet During Brain Development Provokes Excessive Hypothalamic–pituitary–adrenal Axis Responses to Stress and Behavioral Indices of Depression and Anxiety in Male Rat Offspring Later in Life?

Author

Hui-Feng Chen; Hui-Min Su

Publisher

Elsevier BV

Published

2013

Language

EN

Field

Medicine (Health Sciences)