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Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease by Xiao, Xuewen; Liu, Xixi; Jiao, Bin is a Medicine article available to read on EtoBox.

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This review summarizes recent findings on the epigenetics of Alzheimer's disease (AD) and provides therapeutic strategies for AD. We searched the following keywords: "genetics," "epigenetics," "Alzheimer's disease," "DNA methylation," "DNA hydroxymethylation," "histone modifications," "non-coding RNAs," and "therapeutic strategies" in PubMed. In this review, we summarizes recent studies of epigenetics in AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs. There are no consistent results of global DNA methylation/hydroxymethylation in AD. Epigenetic genome-wide association studies show that many differentially methylated sites exist in AD. Several studies investigate the role of histone modifications in AD; for example, histone acetylation decreases, whereas H3 phosphorylation increases significantly in AD. In addition, non-coding RNAs, such as and BACE1-antisense transcript (), are associated with the pathology of AD. These epigenetic changes provide us with novel insights into the pathogenesis of AD and may be potential therapeutic strategies for AD. Epigenetics is associated with the pathogenesis of AD, including DNA methylation/hydroxyme

Who reads Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease?

Author

Xiao, Xuewen; Liu, Xixi; Jiao, Bin

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1664-2295)

Published

2020

Language

EN

Field

Medicine (Health Sciences)