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A Gerophysiology Perspective on Healthy Ageing by Ph. Kemoun; I. Ader; V. Planat-Benard; C. Dray; N. Fazilleau; P. Monsarrat; B. Cousin; J. Paupert; M. Ousset; A. Lorsignol; I. Raymond-Letron; B. Vellas; P. Valet; T. Kirkwood; J. Beard; L. Pénicaud; L. Casteilla is a Medicine article available to read on EtoBox.

What is A Gerophysiology Perspective on Healthy Ageing about?

Improvements in public health and health care have resulted in significant increases in lifespan globally, but also in a significant increase in chronic disease prevalence. This has led to a focus on healthy ageing bringing a shift from a pathology-centered to an intrinsic capacity and function-centered view. In parallel, the emerging field of geroscience has promoted the exploration of the biomolecular drivers of ageing towards a transverse vision by proposing an integrated set of molecular hallmarks. In this review, we propose to take a step further in this direction, highlighting a gerophysiological perspective that considers the notion of homeostasis/allostasis relating to robustness/fragility respectively. While robustness is associated with homeostasis achieved by an optimal structure/function relationship in all organs, successive repair processes occurring after daily injuries and infections result in accumulation of scar healing leading to progressive tissue degeneration, allostasis and frailty. Considering biological ageing as the accumulation of scarring at the level of the whole organism emphasizes three transverse and shared elements in the bodymesenchymal stroma cells

Who reads A Gerophysiology Perspective on Healthy Ageing?

Author

Ph. Kemoun; I. Ader; V. Planat-Benard; C. Dray; N. Fazilleau; P. Monsarrat; B. Cousin; J. Paupert; M. Ousset; A. Lorsignol; I. Raymond-Letron; B. Vellas; P. Valet; T. Kirkwood; J. Beard; L. Pénicaud; L. Casteilla

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)