About this document
Em 20552 by Anton Melcher is a document available to read on EtoBox.
The document discusses targeting mitochondria for cancer therapy. It reviews how cancers often have defects in mitochondrial apoptotic pathways and how increased expression of antiapoptotic proteins like BCL-2 occurs in many cancer types. The BCL-2 family regulates mitochondrial apoptosis and BCL-2 inhibits this pathway. Emerging understanding of these proteins provides opportunities to develop therapies targeting mitochondria.
- Author
- Anton Melcher
- Language
- EN