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Immunity to experimental infection with Leishmania major: generation of protective L3T4+ T cell clones recognizing antigen(s) associated with live parasites by Ingrid Müller; Jacques A. Louis is a Immunology and Microbiology article available to read on EtoBox.
What is Immunity to experimental infection with Leishmania major: generation of protective L3T4+ T cell clones recognizing antigen(s) associated with live parasites about?
## Immunity to experimental infection with Leishmania major: generation of protective L3T4' T cell clones recognizing antigen(s) associated with live parasites* Exacerbation and resolution of lesions induced by Leishmania major promastigotes are, at least in part, the result of the activity of distinct parasite-specific L3T4' T lymphocytes. The present report describes L. major-specific cloned L3T4+ T lymphocytes capable of transferring substantial protective immunity to normal highly susceptible BALB/c mice. The two protective T cell clones analyzed appear to recognize antigen associated only with live L. major parasites. Therefore, the pattern of antigen reactivity of these protective T cell clones is different from that of the previously described parasite-specific L3T4' T cells which contribute to exacerbation of disease. The results presented in this report indicate that the two opposite effects of parasitespecific L3T4' T cells on the disease process could be mediated by functionally similar L3T4' T cells differing in their antigen specificity.
Who reads Immunity to experimental infection with Leishmania major: generation of protective L3T4+ T cell clones recognizing antigen(s) associated with live parasites?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Ingrid Müller; Jacques A. Louis
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)
- Published
- 1989
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)