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The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect by Miquel Adrover; Bartolomé Vilanova; Juan Frau; Francisco Muñoz; Josefa Donoso is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Amadori compounds act as precursors in the formation of advanced glycation end products (AGEs) by non-enzymatic protein glycation, which are involved in ensuing protein damage. Pyridoxamine is a potent drug against protein glycation, and can act on several pathways in the glycation process. Nevertheless, the pyridoxamine inhibition action on Amadori compounds oxidation is still unclear. In this work, we have studied the Schiff base formation between pyridoxamine and various Amadori models at pH 7.4 at 37 °C in the presence of NaCNBH 3 . We detected an adduct formation, which suggests that pyridoxamine reacts with the carbonyl group in Amadori compounds. The significance of this mechanism is tested by comparison of the obtained kinetics rate constants with that obtained for 4-(aminomethyl)-pyridine, a structural analogue of pyridoxamine without post-Amadori action. We also study the chelating effect of pyridoxamine on metal ions. We have determined the complexation equilibrium constants between pyridoxamine, N-(1-deoxy-D D-fructos-1-yl)-L L-tryptophan, aminoguanidine, and ascorbic acid in the presence of Zn 2+ . The results show that the strong stability of pyridoxamine complexes is

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Author

Miquel Adrover; Bartolomé Vilanova; Juan Frau; Francisco Muñoz; Josefa Donoso

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)