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Can I read Impaired Echinocytic Transformation of Ankyrin- and Spectrin-deficient Erythrocytes in Mice on EtoBox?
Impaired Echinocytic Transformation of Ankyrin- and Spectrin-deficient Erythrocytes in Mice by Dr. Walter H. Reinhart; L.-P. Amy Sung; K.-L. Sung; Seldon E. Bernstein; Shu Chien is a Medicine article available to read on EtoBox.
What is Impaired Echinocytic Transformation of Ankyrin- and Spectrin-deficient Erythrocytes in Mice about?
The membrane skeleton of the red blood cell plays an Important role In the determination of cell deformablllty and cell shape. Under various in vitro conditions, red blood cells undergo an echinocytic or stomatocytic shape transformation. The mechanism of this fundamental process Is not well understood. We have studied the red cell shape transformation In normoblastlc anemia mice (nbhb) and spherocytic anemia mice (sphhph), which are deficient in ankyrin and spectrln, respectively. We found that both ankyrlndeflclent cells (nbhb) and spectrln-deficient cells (sphlsph) have a reduced capacity to undergo echinocytic transformation with various echlnocytogenlc treatments, that Is, Incubation with sodlum sallcylate (40 and 120 mM), calcium loading (50 pM A23187 + 2.2 mM Ca2+), or metabolic depletion (24 hr at 37OC). These results suggest that the functional Integrity of the membrane skeleton Is essential for the maintenance and transformation of the red cell shape.
Who reads Impaired Echinocytic Transformation of Ankyrin- and Spectrin-deficient Erythrocytes in Mice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. Walter H. Reinhart; L.-P. Amy Sung; K.-L. Sung; Seldon E. Bernstein; Shu Chien
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)
- Published
- 1988
- Language
- EN
- Field
- Medicine (Health Sciences)