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Novel Schiff Bases as Topoisomerase IIβ Inhibitors by Eka Agustin is a document available to read on EtoBox.
1) The document describes the synthesis of novel Schiff base compounds incorporating a pyranoquinolinedione moiety as potential inhibitors of topoisomerase IIβ. 2) The compounds were evaluated for their topoisomerase IIβ inhibitory activity and cytotoxicity against breast cancer cells. Several compounds showed high docking scores and inhibition of the enzyme. 3) A molecular docking study was performed to investigate the binding properties of the compounds to topoisomerase IIβ and their ability to intercala
- Author
- Eka Agustin
- Language
- EN