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This document reviews the cecal ligation and puncture (CLP) model of polymicrobial sepsis. CLP involves tying off and puncturing the cecum of an animal, allowing intestinal bacteria to leak into the abdomen and bloodstream, closely mimicking human sepsis. While CLP is considered the gold standard animal model, several therapies found effective in CLP failed in human clinical trials. This demonstrates that no animal model fully captures the complexity of human sepsis. The document proposes strategies to narr

Author

nandhus2227

Language

EN