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The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis by John Mair-Jenkins; Maria Saavedra-Campos; J. Kenneth Baillie; Paul Cleary; Fu-Meng Khaw; Wei Shen Lim; Sophia Makki; Kevin D. Rooney; Jonathan S. Nguyen-Van-Tam; Charles R. Beck; Convalescent Plasma Study Group is a Medicine article available to read on EtoBox.

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## Abstract **__Background.__** Administration of convalescent plasma, serum, or hyperimmune immunoglobulin may be of clinical benefit for treatment of severe acute respiratory infections (SARIs) of viral etiology. We conducted a systematic review and exploratory meta-analysis to assess the overall evidence. **__Methods.__** Healthcare databases and sources of grey literature were searched in July 2013. All records were screened against the protocol eligibility criteria, using a 3-stage process. Data extraction and risk of bias assessments were undertaken. **__Results.__** We identified 32 studies of SARS coronavirus infection and severe influenza. Narrative analyses revealed consistent evidence for a reduction in mortality, especially when convalescent plasma is administered early after symptom onset. Exploratory post hoc meta-analysis showed a statistically significant reduction in the pooled odds of mortality following treatment, compared with placebo or no therapy (odds ratio, 0.25; 95% confidence interval, .14–.45; I^2^ = 0%). Studies were commonly of low or very low quality, lacked control groups, and at moderate or high risk of bias. Sources of clinical and methodological he

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Author

John Mair-Jenkins; Maria Saavedra-Campos; J. Kenneth Baillie; Paul Cleary; Fu-Meng Khaw; Wei Shen Lim; Sophia Makki; Kevin D. Rooney; Jonathan S. Nguyen-Van-Tam; Charles R. Beck; Convalescent Plasma Study Group

Publisher

Oxford University Press (OUP)

Published

2014

Language

EN

Field

Medicine (Health Sciences)