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Effects of simvastatin, acetylsalicylic acid, and rosiglitazone on proliferation of normal and cancerous prostate epithelial Cells at therapeutic concentrations by Teemu J. Murtola; Pasi Pennanen; Heimo Syvälä; Merja Bläuer; Timo Ylikomi; Teuvo L.J. Tammela is a Medicine article available to read on EtoBox.
What is Effects of simvastatin, acetylsalicylic acid, and rosiglitazone on proliferation of normal and cancerous prostate epithelial Cells at therapeutic concentrations about?
## Abstract ## BACKGROUND Non‐steroidal anti‐inflammatory drugs and cholesterol‐lowering statins have been reported to inhibit prostate cancer cell growth suggesting their chemopreventive potential within the prostate. However, the effect has been demonstrated only with advanced prostate cancer cell lines and with drug concentrations above the clinical therapeutic range. In this study we compared the effect of therapeutic concentrations of acetylsalicylic acid, simvastatin and rosiglitazone on the growth of a set of prostatic primary cultures and various prostate epithelial cell lines. ## METHODS Two primary epithelial cell lines isolated from surgical resecates of normal prostate tissue (P96E, P97E), a primary cell line isolated from untreated prostate carcinoma (ESTO1), two transformed prostate epithelial cell lines (PWR1‐E, RWPE‐1) and advanced cancer cell lines LNCaP and VCaP were used in the study. Cells were treated for seven days with therapeutic concentrations of acetylsalisylic acid, simvastatin, rosiglitazone or their combination. Cellular growth rate was measured by crystal violet staining method. ## RESULTS Acetylsalicylic acid (0.5 mM) and simvastatin (10 nM) inhibited
Who reads Effects of simvastatin, acetylsalicylic acid, and rosiglitazone on proliferation of normal and cancerous prostate epithelial Cells at therapeutic concentrations?
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- Author
- Teemu J. Murtola; Pasi Pennanen; Heimo Syvälä; Merja Bläuer; Timo Ylikomi; Teuvo L.J. Tammela
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)