Can I read Investigation on Effect of Drug Dosing Regiments on Drug Delivery in Solid Tumor Via Lumped Parameter Modeling and Animal Experiments on EtoBox?

Investigation on Effect of Drug Dosing Regiments on Drug Delivery in Solid Tumor Via Lumped Parameter Modeling and Animal Experiments by Ci-xiu Gao; Shi-xiong Xu; Yu-ping Jiang; Jiang-long Tu is a Engineering article available to read on EtoBox.

What is Investigation on Effect of Drug Dosing Regiments on Drug Delivery in Solid Tumor Via Lumped Parameter Modeling and Animal Experiments about?

This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration (C t ) of tumor interstitium in two types of dosing regiments (i.e., single-shot and triple-shot ones). The two regiments were performed via antitumor drug, hydroxycamptothecin (HCPT), on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.

Who reads Investigation on Effect of Drug Dosing Regiments on Drug Delivery in Solid Tumor Via Lumped Parameter Modeling and Animal Experiments?

Author

Ci-xiu Gao; Shi-xiong Xu; Yu-ping Jiang; Jiang-long Tu

Publisher

Springer-Verlag; Chinese Ocean Press; Springer Science and Business Media LLC (ISSN 1001-6058)

Published

2009

Language

EN

Field

Engineering (Physical Sciences)