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Generalized immune activation as a direct result of activated CD4+ T cell killing by Rute Marques; Adam Williams; Urszula Eksmond; Andy Wullaert; Nigel Killeen; Manolis Pasparakis; Dimitris Kioussis; George Kassiotis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background: In addition to progressive cd4(+) t cell immune deficiency, hiv infection is characterized by generalized immune activation, thought to arise from increased microbial exposure resulting from diminishing immunity. ## Results: Here we report that, in a virus-free mouse model, conditional ablation of activated cd4(+) t cells, the targets of immunodeficiency viruses, accelerates their turnover and produces cd4(+) t cell immune deficiency. more importantly, activated cd4(+) t cell killing also results in generalized immune activation, which is attributable to regulatory cd4(+) t cell insufficiency and preventable by regulatory cd4(+) t cell reconstitution. immune activation in this model develops independently of microbial exposure. furthermore, microbial translocation in mice with conditional disruption of intestinal epithelial integrity affects myeloid but not t cell homeostasis. ## Conclusions: Although neither ablation of activated cd4(+) t cells nor disruption of intestinal epithelial integrity in mice fully reproduces every aspect of hiv-associated immune dysfunction in humans, ablation of activated cd4(+) t cells, but not disruption of intestinal epithelial integri

Who reads Generalized immune activation as a direct result of activated CD4+ T cell killing?

Author

Rute Marques; Adam Williams; Urszula Eksmond; Andy Wullaert; Nigel Killeen; Manolis Pasparakis; Dimitris Kioussis; George Kassiotis

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, c2002-2010.; Springer Science and Business Media LLC (ISSN 1475-4924)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)