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A Comparison of the Phototoxicity of Protoporphyrin, Coproporphyrin and Uroporphyrin Using a Cellular System in Vitro by I. Aravind Menon; Suruj D. Persad; Herbert F. Haberman is a Medicine article available to read on EtoBox.

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The photobiolog,cal effects of protoporphyrin (PP), coproporphyrin (CP) and uroporphyrm (UP) were investigated using an in vitro model. Suspensions of Ehrhch ascites carcinoma ceils were labelled with ~Cr and irradiated m the presence of a wide range of concentrattons of PP, CP and UP. It was found that PP was the most potent-photosensitizer in this system; CP was less effective than PP and UP was the least potent. The cell lysts by CP was enhanced by superoxide dismutase (SOD) and inhibited by catalase; the lysis by UP was also inhibited by catalase; on the other hand, the lysls by PP was not affected by SOD or catalase. These indicate that the cell lysis by CP and UP was largely due to hydrogen peroxide produced from superoxide formed during the irradiation. The lysis produced by PP was not mediated by hydrogen peroxide. These differences in the mechanisms of the phototoxicity of the various porphyrins may have relevance in the etiology and treatment of the porphynas.

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Author

I. Aravind Menon; Suruj D. Persad; Herbert F. Haberman

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

1989

Language

EN

Field

Medicine (Health Sciences)