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Can I read Ameliorative effect of Alangium chinense (Lour.) Harms on rheumatoid arthritis by reducing autophagy with targeting regulate JAK3-STAT3 and COX-2 pathways on EtoBox?
Ameliorative effect of Alangium chinense (Lour.) Harms on rheumatoid arthritis by reducing autophagy with targeting regulate JAK3-STAT3 and COX-2 pathways by Ting Xiao; Xingyan Cheng; Yuan Zhi; Fangfang Tian; Ai Wu; Feilong Huang; Ling Tao; Zhenghong Guo; Xiangchun Shen is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Ameliorative effect of Alangium chinense (Lour.) Harms on rheumatoid arthritis by reducing autophagy with targeting regulate JAK3-STAT3 and COX-2 pathways about?
Ethnopharmacological relevance: Alangium chinense has been used as traditional folk medicine for centuries to treat rheumatoid arthritis (RA) by Guizhou Miao nationality with remarkable clinical effect. But the mechanism of its anti-RA is not fully clarified. Aim of the study: To explore the effect and underlying mechanism of \(A\). chinense against RA. Material and methods: RA rats were induced by CII/IFA, and oral administrated with or without ethyl acetate extracts of Alangium chinense (ACEE) and tripterygium glycosides (GTW). Then arthritis scores, inflammatory factors in serum and histological evaluation were evaluated to assess the degree of joints disease. Proteomics were conducted via LC-MS/MS to clarify the mechanism of ACEE preliminarily, and further examined by immunohistochemistry, immunofluorescence, western botting, and molecular docking. Results: ACEE decreased joints swelling, cell abscission and necrosis of joint tissues arthropathy of RA rats, and attenuated expression of TNF- \(\alpha\), IL-1 \(\beta\), IL-6, PGE2, TGF- \(\beta\). Meanwhile, differentially expressed proteins in the ACEE treated groups were observed, which were involved in RA, spliceosome, cell ad
Who reads Ameliorative effect of Alangium chinense (Lour.) Harms on rheumatoid arthritis by reducing autophagy with targeting regulate JAK3-STAT3 and COX-2 pathways?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Ting Xiao; Xingyan Cheng; Yuan Zhi; Fangfang Tian; Ai Wu; Feilong Huang; Ling Tao; Zhenghong Guo; Xiangchun Shen
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)