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Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle by Nika Rajabian; Izuagie Ikhapoh; Shahryar Shahini; Debanik Choudhury; Ramkumar Thiyagarajan; Aref Shahini; Joseph Kulczyk; Kendall Breed; Shilpashree Saha; Mohamed Alaa Mohamed; Susan B. Udin; Aimee Stablewski; Kenneth Seldeen; Bruce R. Troen; Kirkwood Personius; Stelios T. Andreadis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle about?
## Abstract We investigate the age-related metabolic changes that occur in aged and rejuvenated myoblasts using in vitro and in vivo models of aging. Metabolic and signaling experiments reveal that human senescent myoblasts and myoblasts from a mouse model of premature aging suffer from impaired glycolysis, insulin resistance, and generate Adenosine triphosphate by catabolizing methionine via a methionine adenosyl-transferase 2A-dependant mechanism, producing significant levels of ammonium that may further contribute to cellular senescence. Expression of the pluripotency factor NANOG downregulates methionine adenosyltransferase 2 A, decreases ammonium, restores insulin sensitivity, increases glucose uptake, and enhances muscle regeneration post-injury. Similarly, selective inhibition of methionine adenosyltransferase 2 A activates Akt2 signaling, repairs pyruvate kinase, restores glycolysis, and enhances regeneration, which leads to significant enhancement of muscle strength in a mouse model of premature aging. Collectively, our investigation indicates that inhibiting methionine metabolism may restore age-associated impairments with significant gain in muscle function.
Who reads Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nika Rajabian; Izuagie Ikhapoh; Shahryar Shahini; Debanik Choudhury; Ramkumar Thiyagarajan; Aref Shahini; Joseph Kulczyk; Kendall Breed; Shilpashree Saha; Mohamed Alaa Mohamed; Susan B. Udin; Aimee Stablewski; Kenneth Seldeen; Bruce R. Troen; Kirkwood Personius; Stelios T. Andreadis
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)