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Can I read Engineering a Macroporous Oxygen-generating Scaffold for Enhancing Islet Cell Transplantation Within an Extrahepatic Site on EtoBox?
Engineering a Macroporous Oxygen-generating Scaffold for Enhancing Islet Cell Transplantation Within an Extrahepatic Site by Jia-Pu Liang; Robert P. Accolla; Madhuvanthi Soundirarajan; Amy Emerson; Maria M. Coronel; Cherie L. Stabler is a Engineering article available to read on EtoBox.
What is Engineering a Macroporous Oxygen-generating Scaffold for Enhancing Islet Cell Transplantation Within an Extrahepatic Site about?
Insufficient oxygenation is a serious issue arising within cell-based implants, as the hypoxic period between implantation and vascularization of the graft is largely unavoidable. In situ oxygen supplementation at the implant site should significantly mitigate hypoxia-induced cell death and dysfunction, as well as improve transplant efficacy, particularly for highly metabolically active cells such as pancreatic islets. One promising approach is the use of an oxygen generating material created through the encapsulation of calcium peroxide within polydimethylsiloxane (PDMS), termed OxySite. In this study, OxySite microbeads were incorporated within a macroporous PDMS scaffold to create a single, streamlined, oxygen generating macroporous scaffold. The resulting OxySite scaffold generated sufficient local oxygenation for up to 20 days, with nontoxic levels of reaction intermediates or by-products. The benefit of local oxygen release on transplant efficacy was investigated in a diabetic Lewis rat syngeneic transplantation model using a clinically relevant islet dosage (10,000 IEQ/kg BW) with different isolation purities (80%, 90%, and 99%). Impure islet preparations containing pancreat
Who reads Engineering a Macroporous Oxygen-generating Scaffold for Enhancing Islet Cell Transplantation Within an Extrahepatic Site?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Jia-Pu Liang; Robert P. Accolla; Madhuvanthi Soundirarajan; Amy Emerson; Maria M. Coronel; Cherie L. Stabler
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)