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Alginate-Based Electrospun Membranes Containing ZnO Nanoparticles as Potential Wound Healing Patches: Biological, Mechanical, and Physicochemical Characterization by Andrea Dodero; Sonia Scarfi; Marina Pozzolini; Silvia Vicini; Marina Alloisio; Maila Castellano is a Engineering article available to read on EtoBox.
What is Alginate-Based Electrospun Membranes Containing ZnO Nanoparticles as Potential Wound Healing Patches: Biological, Mechanical, and Physicochemical Characterization about?
In the present work, alginate-based mats with and without ZnO nanoparticles were prepared via electrospinning technique and subjected to a washing-crosslinking process to obtain highly stable products characterized by thin and homogeneous nanofibers with a diameter of 100 ± 30 nm. Using a commercial collagen product as control, the biological response of the prepared mats was carefully evaluated with particular attention paid to the influence of the used crosslinking agent (Ca 2+ or Sr 2+ or Ba 2+ ions) and to the presence of the nanofillers. Fibroblast and keratinocyte cultures successfully proved the safety of the prepared alginatebased mats, whereas ZnO nanoparticles were found to provide strong anti-bacteriostatic and anti-bacterial properties; above all, the strontium-and barium-crosslinked samples showed performances in terms of cell adhesion and growth very similar to those of the commercial collagen membrane despite they showed a significant lower protein adsorption. Moreover, the mechanical and water-related properties of the strontium-crosslinked mats embedding ZnO nanoparticles were proven to be similar to those of human skin (i.e Young Modulus of 470 MPa and water vapou
Who reads Alginate-Based Electrospun Membranes Containing ZnO Nanoparticles as Potential Wound Healing Patches: Biological, Mechanical, and Physicochemical Characterization?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Andrea Dodero; Sonia Scarfi; Marina Pozzolini; Silvia Vicini; Marina Alloisio; Maila Castellano
- Published
- 2019
- Language
- EN
- Field
- Engineering (Physical Sciences)