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Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF‐κB and PPAR-γ pathways by Maged E. Mohamed; Sahar A. Elsayed; Hafez R. Madkor; Heba M. Saad Eldien; Omar M. Mohafez is a Medicine article available to read on EtoBox.

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## Background/Aims Ulcerative colitis (UC) is a chronic inflammatory disorder with indefinite etiology; however, environmental, genetic, immune factors and microbial agents could be implicated in its pathogenesis. UC treatment is lifelong, therefore; the potential side effects and cost of the therapy are significant. Yarrow is a promising medicinal plant with the ability to treat many disorders, owing to its bioactive compounds especially the essential oil. The main aim of this research was to investigate the therapeutic effect of the yarrow oil on colitis including the involved mechanism of action. ## Methods In 21-female C57BL/6 mice were divided into 3 groups; control group, colitis model group, and oil-treated group. Groups 2 and 3 received 5% dextran sulfate sodium (DSS) in drinking water for 9 days, and concomitantly, only group 3 was given 100 mg/kg yarrow oil. Mice were examined for their body weight, stool consistency and bleeding, and the disease activity indexes were calculated. ## Results Oral administration of yarrow oil markedly repressed the severity of UC via the reduction of the inflammatory signs and restoring colon length. The oil was able to down-regulate nuclea

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Author

Maged E. Mohamed; Sahar A. Elsayed; Hafez R. Madkor; Heba M. Saad Eldien; Omar M. Mohafez

Publisher

Korean Association for the Study of Intestinal Diseases

Published

2020

Language

EN

Field

Medicine (Health Sciences)