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Molecular Pathogenesis and Therapeutic Targets in Epithelial Ovarian Cancer by Jeremy R. Chien; Giovanni Aletti; Debra A. Bell; Gary L. Keeney; Viji Shridhar; Lynn C. Hartmann is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Molecular Pathogenesis and Therapeutic Targets in Epithelial Ovarian Cancer about?

## Abstract Ovarian cancer, the most aggressive gynecologic cancer, is the foremost cause of death from gynecologic malignancies in the developed world. Two primary reasons explain its aggressive behavior: most patients present with advanced disease at diagnosis, and die of recurrences from disease that has become resistant to conventional chemotherapies. In this paper on epithelial ovarian cancer (EOC), we will review molecular alterations associated with the few precursor lesions identified to date, followed by the more commonly recognized processes of de novo carcinogenesis, metastasis, and the development of chemoresistance. We will propose a unifying model of ovarian epithelial tumorigenesis that takes into account various hypotheses. We will also review novel approaches to overcome the major problem of chemoresistance in ovarian cancer. Finally, we will discuss advances and new challenges in the development of mouse model systems to investigate EOC precursor lesions, progression, metastasis, and chemoresistance. J. Cell. Biochem. 102: 1117–1129, 2007. © 2007 Wiley‐Liss, Inc.

Who reads Molecular Pathogenesis and Therapeutic Targets in Epithelial Ovarian Cancer?

Author

Jeremy R. Chien; Giovanni Aletti; Debra A. Bell; Gary L. Keeney; Viji Shridhar; Lynn C. Hartmann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)