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Safety and Efficacy of Robotic Radiosurgery for Visceral and Lymph Node Metastases of Renal Cell Carcinoma: A Retrospective, Single Center Analysis by Rodler, Severin (author);Schott, Melanie (author);Tamalunas, Alexander (author);Marcon, Julian (author);Graser, Annabel (author);Mumm, Jan-Niclas (author);Casuscelli, Jozefina (author);Stief, Christian G. (author);Fürweger, Christoph (author);Muacevic, Alexander (author);Staehler, Michael (author) is a Medicine article available to read on EtoBox.

What is Safety and Efficacy of Robotic Radiosurgery for Visceral and Lymph Node Metastases of Renal Cell Carcinoma: A Retrospective, Single Center Analysis about?

Despite rapid advances of systemic therapy options in renal cell carcinoma (RCC), local tumor or metastases treatment remains important in selected patients. Here, we assess the safety and efficacy of robotic radiosurgery (RRS) as an ablative therapy for visceral and lymph node metastases of RCC. Patients with histologically confirmed RCC and radiologically confirmed progression of visceral or lymph node metastases underwent RRS and were retrospectively analyzed. Overall survival and progression free survival were calculated by the Kaplan–Meier method and log-rank test. Sixty patients underwent RRS and were included in the analysis. Patients presented for RRS treatment with a median age at RRS treatment of 64 years (range 42–83), clear cell histology (88.3%) and favorable international metastatic renal cell carcinoma database (IMDC) risk score (58.3%). Treatment parameters differed for the number of fractions (median visceral metastases: 1, range 1–5; median lymph node metastases: 1, range 0–5; p = 0.003) and prescription dose (median visceral metastases 24 Gy, range 8–26; median lymph node metastases 18 Gy, range 7–26, p < 0.001). The median overall survival was 65.7 months (range

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Author

Rodler, Severin (author);Schott, Melanie (author);Tamalunas, Alexander (author);Marcon, Julian (author);Graser, Annabel (author);Mumm, Jan-Niclas (author);Casuscelli, Jozefina (author);Stief, Christian G. (author);Fürweger, Christoph (author);Muacevic, Alexander (author);Staehler, Michael (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)