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Urinary Orosomucoid: a Novel, Early Biomarker of Sepsis with Promising Diagnostic Performance by Péter Kustán; Balázs Szirmay; Zoltán Horváth-Szalai; Andrea Ludány; Gábor L. Kovács; Attila Miseta; Tamás Kőszegi; Diána Mühl is a Medicine article available to read on EtoBox.

What is Urinary Orosomucoid: a Novel, Early Biomarker of Sepsis with Promising Diagnostic Performance about?

## Abstract ## Background: In order to help clinical decision making, we investigated the diagnostic and prognostic ability of urinary orosomucoid (u-ORM) as a new sepsis biomarker, and compared its performance to classical inflammatory parameters. ## Methods: We monitored u-ORM in septic (n=43) and SIRS (n=13) patients in a 5-day follow-up study vs. control patients (n=30). U-ORM was measured by a newly developed turbidimetric assay. U-ORM values were referred to urinary creatinine and expressed as u-ORM/u-CREAT (mg/mmol). ## Results: Significantly higher (p<0.001) u-ORM/u-CREAT levels were found in sepsis than in SIRS. Both intensive care unit (ICU) groups showed strongly elevated values compared to controls (p<0.001). The medians of admission u-ORM/u-CREAT levels were 19.2 in sepsis, 2.1 in SIRS and 0.2 mg/mmol in controls. The area under the receiver operating characteristic curve for distinguishing SIRS from sepsis was found to be 0.954 for u-ORM/u-CREAT, superior to serum ORM and hsCRP. U-ORM levels did not change during the 5-day follow-up and were independent of the severity of sepsis however, we found extremely elevated u-ORM/u-CREAT values in dialyzed septic patients (52.

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Author

Péter Kustán; Balázs Szirmay; Zoltán Horváth-Szalai; Andrea Ludány; Gábor L. Kovács; Attila Miseta; Tamás Kőszegi; Diána Mühl

Publisher

Walter de Gruyter GmbH

Published

2016

Language

EN

Field

Medicine (Health Sciences)