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The role of αB-crystallin as a potential encephalitogen in murine EAE by Marianne J.B. van Stipdonk; Sandra Amor; Astrid A. Borsboom; Perry Verzaal; Paul J. Travers; Claire J.P. Boog; Johannes M. van Noort is a Immunology and Microbiology article available to read on EtoBox.

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supematants from short term hsp60 T cell lines 11-4, IFN-y and TGF-@ were measured. In synovial fluid MNC also the expression of mRNA for IL-4, lL-6, IL-IO and TGF-fl was determined. Results: In vitro prfming with hsp60 of peripheral blood or synovial fluid MNC from patients with OA JCA led to an increased expression of CD30 on CD4+ and CD8+ T cells. Furthermore, short term hsp60 T cell lines from patients with OA JCA, but not from PA JCA patients, were capable of producing II-4 and/or TGF-fi. Finally, we found mRNA expression of II-4 in synovial fluid MNC of the vast majority of patients with OA JCA (8/g), but not in PA JCA patients. In both patient groups mRNA expression of 11-6, II-10 and TGF-/I was found. II-4 mRNA expression in synovtal fluid MNC of patients with OA JCA was associated with responsiveness to hsp60 in synovial fluid MNC. Conclusion: We found evidence for a relationship in OA JCA patients between responsiveness to self hsp60 and the production and expression of regulatory cytokines. Responsiveness to self hsp's may be part of the normal regulatory mechanisms of the immune system to control inflammation. to suppress TNF-a production of freshly isolated mononuclear

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Author

Marianne J.B. van Stipdonk; Sandra Amor; Astrid A. Borsboom; Perry Verzaal; Paul J. Travers; Claire J.P. Boog; Johannes M. van Noort

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)