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Cortical Topological Network Changes Following Optic Neuritis by Backner, Yael; Ben-Shalom, Ido; Kuchling, Joseph; Siebert, Nadja; Scheel, Michael; Ruprecht, Klemens; Brandt, Alexander; Paul, Friedemann; Levin, Netta is a Medicine article available to read on EtoBox.

What is Cortical Topological Network Changes Following Optic Neuritis about?

## Objective To differentiate between visual cortical network topology changes following optic neuritis (ON) stemming from different inflammatory disease types, we used mathematical graph theory–based tools to analyze functional imaging data. ## Methods Sixty-two patients were recruited into this cross-sectional study, 23 of whom had neuromyelitis optica spectrum disorder (NMOSD) with ON, 18 with clinically isolated syndrome (CIS)-ON, and 21 with other CIS episodes. Twenty-six healthy controls (HCs) were also recruited. All participants underwent resting-state functional MRI. Visual networks were defined using 50 visual regions of interest. Analysis included graph theory metrics, including degree, density, modularity, and local and global efficiency. ## Results Visual network density shows decreased connectivity in all patient groups compared with controls. A higher degree of connections is seen in both ON groups (CIS and NMOSD) compared with the the non-ON group. This pattern is most pronounced in dorsal-lateral regions. Information transfer efficiency and modularity were reduced in both CIS groups, but not in the NMOSD group, compared with the HC group. ## Conclusions Visual netw

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Author

Backner, Yael; Ben-Shalom, Ido; Kuchling, Joseph; Siebert, Nadja; Scheel, Michael; Ruprecht, Klemens; Brandt, Alexander; Paul, Friedemann; Levin, Netta

Publisher

Ovid Technologies (Wolters Kluwer) - American Academy of Neurology; Lippincott Williams and Wilkins; Ovid Technologies (Wolters Kluwer Health) (ISSN 2332-7812)

Published

2020

Language

EN

Field

Medicine (Health Sciences)