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Impact of Proximal Resection Margin Involvement on Survival Outcome in Patients with Proximal Gastric Cancer by Bochao Zhao; Huiwen Lu; Shiyang Bao; Rui Luo; Di Mei; Huimian Xu; Baojun Huang is a Medicine article available to read on EtoBox.

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Aim The aim of this study was to evaluate the risk factors for proximal resection margin involvement and its impact on survival outcome in patients with proximal gastric cancer. Methods A total of 488 patients who underwent potentially curative resection for proximal gastric cancer were retrospectively reviewed. Clinicopathological characteristics and survival differences between patients with positive and negative resection margins were compared and prognostic factors were determined by Cox multivariate analysis. Results In this study, 7.6% (37/488) of patients with proximal gastric cancer had a positive proximal resection margin after postoperative histopathological examination. Positive resection margins were significantly associated with advanced tumour stage and more aggressive biological features including larger tumour size, serosal invasion and lymphovascular invasion. Serosal invasion (OR 4.543, 95% CI 2.201 to 9.380, p<0.001) and lymphovascular invasion (OR 2.279, 95% CI 1.129 to 4.600, p<0.05) were independent risk factors for positive proximal resection margins. In terms of survival outcome, positive resection margins had an adverse impact on the prognosis of patients w

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Author

Bochao Zhao; Huiwen Lu; Shiyang Bao; Rui Luo; Di Mei; Huimian Xu; Baojun Huang

Publisher

BMJ Publishing Group

Published

2019

Language

EN

Field

Medicine (Health Sciences)