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Interaction of neuropsychiatric symptoms with APOE Îμ4 and conversion to dementia in MCI patients in a Memory Clinic by Sergi, Valero; Marta, Marquié; De Itziar, Rojas; Ana, Espinosa; Sonia, Moreno-Grau; Adelina, Orellana; Laura, Montrreal; Isabel, Hernández; Ana, Mauleón; Maitée, Rosende-Roca; Montse, Alegret; Alba, Pérez-Cordón; Gemma, Ortega; Natalia, Roberto; Angela, Sanabria; Carla, Abdelnour; Silvia, Gil; Juan Pablo, Tartari; Liliana, Vargas; Ester, Esteban-De Antonio; Alba, Benaque; Lluís, Tárraga; Mercà̈, Boada; Agustín, Ruíz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract To date, very few studies have been focused on the impact of the convergence of neuropsychiatric symptoms (NPS) and APOE ε4 on the conversion to dementia in patients with Mild Cognitive Impairment patients (MCI), and none has been based in a clinical setting. The objective of the study is to determine the predictive value of additive and multiplicative interactions of NPS and APOE ε4 status on the prediction of incident dementia among MCI patients monitored in a Memory Clinic. 1512 patients (aged 60 and older) with prevalent MCI were followed for a mean of 2 years. Neuropsychiatric symptoms were assessed at baseline using the Neuropsychiatric Inventory Questionnaire. Cox proportional hazards models were calculated. Additive interactions for depression, apathy, anxiety, agitation, appetite, or irritability and a positive ε4 carrier status were obtained, significantly increasing the hazard ratios of incident dementia (HR range 1.3–2.03). Synergistic interactions between NPS and APOE ε4 are identified among MCI patients when predicting incident dementia. The combination of the behavioral status and the genetic trait could be considered a useful strategy to identify the mos

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Author

Sergi, Valero; Marta, Marquié; De Itziar, Rojas; Ana, Espinosa; Sonia, Moreno-Grau; Adelina, Orellana; Laura, Montrreal; Isabel, Hernández; Ana, Mauleón; Maitée, Rosende-Roca; Montse, Alegret; Alba, Pérez-Cordón; Gemma, Ortega; Natalia, Roberto; Angela, Sanabria; Carla, Abdelnour; Silvia, Gil; Juan Pablo, Tartari; Liliana, Vargas; Ester, Esteban-De Antonio; Alba, Benaque; Lluís, Tárraga; Mercà̈, Boada; Agustín, Ruíz

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)