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Studies on the formation of a complex of Cu(II) with sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate – An analogue of the core unit of anthracycline anticancer drugs and its interaction with calf thymus DNA by Partha Sarathi Guin; Saurabh Das; P.C. Mandal is a Chemistry article available to read on EtoBox.

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Copper(II) forms a complex with sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate (sodium quinizarin-2-sulphonate, NaQSH 2 ), an analogue of the core unit of anthracycline antibiotics used in the treatment of cancer. The 1:2 metal-ligand complex is formed in aqueous solution at neutral and acidic pH while in alkaline pH both 1:1 and 1:2 species are formed. The effective stability constant of the 1:2 metal-ligand complex is 9.64 Â 10 16 while that of the 1:1 metal-ligand complex is 9.4 Â 10 9 . The 1:2 complex Cu(NaQSH) 2 (H 2 O) 2 was synthesized and characterized by different techniques in solid state and in solution. The complex Cu(NaQSH) 2 (H 2 O) 2 interacts with calf thymus DNA which was studied by fluorescence spectroscopy. The binding constant and site size for the interaction with DNA were determined.

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Author

Partha Sarathi Guin; Saurabh Das; P.C. Mandal

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)