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Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass at 5 years (YOMEGA): a prospective, open-label, non-inferiority, randomised extension study by Maud Robert; Tigran Poghosyan; Delphine Maucort-Boulch; Alexandre Filippello; Robert Caiazzo; Adrien Sterkers; Lita Khamphommala; Fabian Reche; Vincent Malherbe; Adriana Torcivia; Toufic Saber; Dominique Delaunay; Carole Langlois-Jacques; Augustin Suffisseau; Sylvie Bin; Emmanuel Disse; François Pattou is a Medicine article available to read on EtoBox.

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## Background The multicentre randomised trial YOMEGA (NCT02139813) comparing the one anastomosis gastric bypass (OAGB) with the Roux-en-Y gastric bypass (RYGB) confirmed the non-inferiority of OAGB on weight loss outcomes at 24 months. We aimed to report weight loss, metabolic, and safety outcomes at 5 years. Methods YOMEGA is a prospective, open-label, non-inferiority, randomised trial conducted at nine centres in France. Inclusion criteria were BMI of 40 kg/m2 or more, or 35 kg/m2 or more with comorbidities. Key exclusion criteria were severe gastro-oesophageal reflux disease or Barrett's oesophagus and previous bariatric surgery. Patients were randomly assigned (1 :1) to OAGB (one gastrojejunal anastomosis with a 200 cm biliopancreatic limb) or RYGB (with a 150 cm alimentary limb and a 50 cm biliary limb), stratified by centre, with blocks of variable size. The primary endpoint of this extension study was percentage excess BMI loss and was analysed in the per-protocol population, including patients with data who were operated on with the technique randomly assigned to them and excluding patients with major deviations from the protocol during the follow-up (change of surgical te

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Author

Maud Robert; Tigran Poghosyan; Delphine Maucort-Boulch; Alexandre Filippello; Robert Caiazzo; Adrien Sterkers; Lita Khamphommala; Fabian Reche; Vincent Malherbe; Adriana Torcivia; Toufic Saber; Dominique Delaunay; Carole Langlois-Jacques; Augustin Suffisseau; Sylvie Bin; Emmanuel Disse; François Pattou

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Medicine (Health Sciences)