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This study investigates the distinct roles of glycocalyx components, heparan sulfate (HS) and sialic acid (SA), in regulating endothelial functions using a three-dimensional human endothelium-on-a-chip model. Findings indicate that HS degradation increases vascular permeability while SA cleavage reduces it, and SA degradation enhances monocyte adhesion. The research highlights the importance of understanding glycocalyx components in the context of endothelial dysfunction and cardiovascular disease.
- Author
- thawaii39
- Language
- EN