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Studies on IgE production in mice: I. Spontaneous suppression of IgE production in SJA/9 mice by Yoshihiro Kumagai; Takao Hirano; Naohiro Watanabe; Ko Okumura; Zoltan Ovar is a Immunology and Microbiology article available to read on EtoBox.

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IgE levels after Nipposrrongylus brasiliensis infestation were high in all strains of mice examined except in the SJA/9 strain. However, surface IgE levels on B cells were not different from those observed in the SJL strain. Most surface IgE-bearing cells also had surface IgM molecules. We suggest that the surface IgE-bearing cells are precursors of IgE-producing cells. In adoptive transfer, hapten-specific IgE antibody was produced when hapten-primed cells from SJA/9 mice were transferred together with cells from SJL donors infested with N. brasiliensis but not when the cells were from SJA/9 donors. It is suggested that the lack of collaboration between hapten-primed B cells and cells from infested mice is a genetic trait of the SJA/9 strain.

Who reads Studies on IgE production in mice: I. Spontaneous suppression of IgE production in SJA/9 mice?

Author

Yoshihiro Kumagai; Takao Hirano; Naohiro Watanabe; Ko Okumura; Zoltan Ovar

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)

Published

1983

Language

EN

Field

Immunology and Microbiology (Life Sciences)