Can I read One Genome, Many Cell States: Epigenetic Control of Innate Immunity on EtoBox?

One Genome, Many Cell States: Epigenetic Control of Innate Immunity by Isabella Fraschilla; Hajera Amatullah; Kate L Jeffrey is a Immunology and Microbiology article available to read on EtoBox.

What is One Genome, Many Cell States: Epigenetic Control of Innate Immunity about?

A hallmark of the innate immune system is its ability to rapidly initiate short-lived or sustained transcriptional programs in a cell-specific and pathogen-specific manner that is dependent on dynamic chromatin states. Much of the epigenetic landscape is set during cellular differentiation; however, pathogens and other environmental cues also induce changes in chromatin that can either promote tolerance or 'train' innate immune cells for amplified secondary responses. We review chromatin processes that enable innate immune cell differentiation and functional transcriptional responses in naive or experienced cells, in concert with signal transduction and cellular metabolic shifts. We discuss how immune chromatin mechanisms are maladapted in disease and novel therapeutic approaches for cellular reprogramming.

Who reads One Genome, Many Cell States: Epigenetic Control of Innate Immunity?

Author

Isabella Fraschilla; Hajera Amatullah; Kate L Jeffrey

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Immunology and Microbiology (Life Sciences)