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Genetic Polymorphisms in Chronic Hyperplastic Sinusitis with Nasal Polyposis by Joel M. Bernstein; Jack B. Anon; Michael Rontal; Jeffrey Conroy; Chong Wang; Lara Sucheston is a Medicine article available to read on EtoBox.

What is Genetic Polymorphisms in Chronic Hyperplastic Sinusitis with Nasal Polyposis about?

## Abstract ## **Objectives/Hypothesis:** Although many proinflammatory cytokines have been identified in nasal polyp tissue, the initial trigger that causes this inflammation characterized by edema, lymphocytosis, and eosinophilia, is still unknown. The purpose of the present study is to identify the presence of genetic polymorphisms in proinflammatory, anti‐inflammatory, and chemokine genes that might contribute to genetic susceptibility to chronic hyperplastic sinusitis with nasal polyposis (CHSwNP). ## **Study Design:** Case control study. ## **Methods:** Buccal swabs were taken from the left and right oral mucosal surfaces from 179 patients with CHSwNP and 153 nonpolyposis controls with the Purgene DNA purification protocol (Gentra). Genotyping assays for cytokine gene loci were performed on 14 cytokine genes using the iPlex Gold and the Mass Array Compact system (Sequenom, San Diego, CA). Tests of Hardy‐Weinberg equilibrium proportions were performed separately in the cases and controls. Tests for evidence of association between alleles at each single‐nucleotide polymorphism (SNP) and case‐control status were performed using unconditional logistic regression. ## **Results:**

Who reads Genetic Polymorphisms in Chronic Hyperplastic Sinusitis with Nasal Polyposis?

Author

Joel M. Bernstein; Jack B. Anon; Michael Rontal; Jeffrey Conroy; Chong Wang; Lara Sucheston

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0023-852X)

Published

2009

Language

EN

Field

Medicine (Health Sciences)