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This study presents a direct method for synthesizing methylphenidate analogues using rhodium(II)-catalyzed C–H insertion with N-Boc-piperidine and N-Boc-pyrrolidine. The resulting compounds exhibit varying binding affinities at dopamine and serotonin transporters, with the erythro-(2-naphthyl) analogues showing notable selectivity for the serotonin transporter. The research highlights the potential for developing new therapeutic agents for conditions like ADHD and cocaine addiction.

Author

weslley.affonso16

Language

EN