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Bone morphogenetic protein acts as a ventral mesoderm modifier in early Xenopus embryos by Atsushi Suzuki; Noriko Shioda; Naoto Ueno is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Mesoderm of early vertebrate embryos gradually acquires dorsal–ventral polarity during embryogenesis. This specification of mesoderm is thought to be regulated by several polypeptide growth factors. Bone morphogenetic protein (BMP), a member of the TGF‐β family, is one of the regulators suggested to be involved in the formation of ventral mesoderm. In this paper, the nature of the endogenous BMP signal in dorsal–ventral specification was assessed in early __Xenopus__ embryos using a dominant negative mutant of the __Xenopus__ BMP receptor. In ectodermal explant assays, disruption of endogenous BMP signaling by the mutant receptor changed the competence of the explant cells to mesoderm‐inducing factors, activin and basic fibroblast growth factor (bFGF), and led to formation of neural tissue without mesoderm induction. This result suggests that endogenous BMP acts as a ventral mesoderm modifier rather than a ventral mesoderm inducer, and that interactions between endogenous BMP and mesoderm‐inducing factors may be important in dorsal–ventral patterning of embryonic mesoderm. In addition, the induction of neural tissue by inhibition of the BMP signaling pathway also suggests involveme

Who reads Bone morphogenetic protein acts as a ventral mesoderm modifier in early Xenopus embryos?

Author

Atsushi Suzuki; Noriko Shioda; Naoto Ueno

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0012-1592)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)