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Hepatitis C virus E2 protein induce reactive oxygen species (ROS)-related fibrogenesis in the HSC-T6 hepatic stellate cell line by Hsieh Ming-Ju; Hsieh Yih-Shou; Chen Tzy-Yen; Chiou Hui-Ling is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Chronic infection of hepatitis C virus (HCV) leads to hepatic fibrosis and subsequently cirrhosis, although the underlying mechanisms have not been established. Previous studies have indicated that the binding of HCV E2 protein and CD81 on the surface of hepatic stellate cells (HSCs) lead to the increased protein level and activity of matrix metallopeptidase (MMP) 2, indicating that E2 may involve in the HCV‐induced fibrosis. This study was designed to investigate the involvement of HCV E2 protein in the hepatic fibrogenesis. Results showed that E2 protein may promote the expression levels of α‐smooth muscle actin (α‐SMA) and collagen α(I). Furthermore, several pro‐fibrosis or pro‐inflammatory cytokines, including transforming growth factor (TGF)‐β1, connective tissue growth factor (CTGF), interleukin (IL)‐6 and IL‐1β, were significantly increased in E2 transfected‐HSC cell lines, while the expression of MMP‐2 are also considerably increased. Moreover, the significant increases of CTGF and TGF‐β1 in a stable E2‐expressing Huh7 cell line were also observed the same results. Further molecular studies indicated that the impact of E2 protein on collagen production related t

Who reads Hepatitis C virus E2 protein induce reactive oxygen species (ROS)-related fibrogenesis in the HSC-T6 hepatic stellate cell line?

Author

Hsieh Ming-Ju; Hsieh Yih-Shou; Chen Tzy-Yen; Chiou Hui-Ling

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)