Can I read Mismatch Repair and Clinical Response to Immune Checkpoint Inhibitors in Endometrial Cancer on EtoBox?

Mismatch Repair and Clinical Response to Immune Checkpoint Inhibitors in Endometrial Cancer by Yoland Antill; Daniel D. Buchanan; Clare L. Scott is a Medicine article available to read on EtoBox.

What is Mismatch Repair and Clinical Response to Immune Checkpoint Inhibitors in Endometrial Cancer about?

## Lay Summary Endometrial cancer is common, and a subset recurs and requires additional treatment. Some of these are recognized as being susceptible to immune therapies and are said to have mismatch repair deficiency (dMMR). However, this clinical trial highlights which cases are more likely to respond well: those containing mutations in genes known as Lynch genes and also some with mutations in POLE/POLD1 (“ultra‐hypermutation” genes). In contrast, the majority of dMMR endometrial cancers have silencing or DNA methylation of one of these genes, __MLH1__, and do not seem to be as responsive to single‐agent immune therapy. The availability of combination therapies may be important to consider for these women.

Who reads Mismatch Repair and Clinical Response to Immune Checkpoint Inhibitors in Endometrial Cancer?

Author

Yoland Antill; Daniel D. Buchanan; Clare L. Scott

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)