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Can I read Harnessing ROS-Induced Oxidative Stress for Halting Colorectal Cancer via Thiazolidinedione-Based SOD Inhibitors on EtoBox?
Harnessing ROS-Induced Oxidative Stress for Halting Colorectal Cancer via Thiazolidinedione-Based SOD Inhibitors by Mohamed Nabil Abd Al Moaty; El Sayed H. El Ashry; Laila Fathy Awad; Asmaa Mostafa; Marwa M. Abu-Serie; Mohamed Teleb is a Engineering article available to read on EtoBox.
What is Harnessing ROS-Induced Oxidative Stress for Halting Colorectal Cancer via Thiazolidinedione-Based SOD Inhibitors about?
Based on the “canonical” view of reactive oxygen species’ (ROS) contribution to carcinogenesis, ROS induce oxidative stress and promote various tumor progression events. However, tumor cells also need to defend themselves against oxidative damage. This “heresy” was supported by several recent studies underlining the role of cellular antioxidant capacity in promoting metastasis and resistance to chemotherapy. Accordingly, harnessing the ROS-induced oxidative stress via selective suppression of the cancer antioxidant defense machinery has been launched as an innovative anticancer strategy. Within this approach, pharmacological inhibition of superoxide dismutases (SODs), the first-line defense antioxidant enzymes for cancer cells, selectively kills tumor cells and circumvents their acquired resistance. Various SOD inhibitors have been introduced, of which some were tolerated in clinical trials. However, the hit SOD inhibitors belong to diverse chemical classes and lack comprehensive structure–activity relationships (SAR). Herein, we probe the potential of newly synthesized benzylidene thiazolidinedione derivatives to inhibit SOD in colorectal cancer with special emphasis on their effe
Who reads Harnessing ROS-Induced Oxidative Stress for Halting Colorectal Cancer via Thiazolidinedione-Based SOD Inhibitors?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Mohamed Nabil Abd Al Moaty; El Sayed H. El Ashry; Laila Fathy Awad; Asmaa Mostafa; Marwa M. Abu-Serie; Mohamed Teleb
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)