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Can I read Encapsulation state of messenger RNA inside lipid nanoparticles on EtoBox?
Encapsulation state of messenger RNA inside lipid nanoparticles by Mark L. Brader; Sean J. Williams; Jessica M. Banks; Wong H. Hui; Z. Hong Zhou; Lin Jin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Encapsulation state of messenger RNA inside lipid nanoparticles about?
Understanding the structure of messenger RNA (mRNA) lipid nanoparticles, and specifically the microenvironment of the mRNA molecules within these entities, is fundamental to advancing their biomedical potential. Here, we show that a permeating cationic dye, thionine, can serve as a cryogenic electron microscopy contrasting agent by binding selectively to encapsulated mRNA without disturbing lipid nanoparticle morphology. Cryo-electron microscopy images identify the mRNA location, revealing that mRNA may exist within solvent-filled cavities or may be substantially lipid associated.
Who reads Encapsulation state of messenger RNA inside lipid nanoparticles?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mark L. Brader; Sean J. Williams; Jessica M. Banks; Wong H. Hui; Z. Hong Zhou; Lin Jin
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)