Opening book details…
Can I read The Specificity of Neuroprotection by Antioxidants on EtoBox?
The Specificity of Neuroprotection by Antioxidants by Yuanbin Liu; David R Schubert is a Medicine article available to read on EtoBox.
What is The Specificity of Neuroprotection by Antioxidants about?
Background: Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS production under conditions of toxic stress is from mitochondria, and multiple antioxidants prevent ROS accumulation. The aim of this study is to examine the specificity of the interaction between the antioxidants and ROS production in stressed cells. Methods: Using fluorescent dyes for ROS detection and mitochondrial inhibitors of known specificities, we studied ROS production under three conditions where ROS are produced by mitochondria: oxidative glutamate toxicity, state IV respiration induced by oligomycin, and tumor necrosis factor-induced cell death. ## Results: We demonstrated that there are at least four mitochondrial ROS-generating sites in cells, including the flavin mononucleotide (FMN) group of complex I and the three ubiquinone-binding sites in complexes I, II and III. ROS production from these sites is modulated in an insult-specific manner and the sites are differentially accessible to common antioxidants. ## Conclusion: The inhibition of ROS accumulation by different antioxidants is specific to the s
Who reads The Specificity of Neuroprotection by Antioxidants?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yuanbin Liu; David R Schubert
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); BioMed Central Ltd.; [Basel Switzerland]: Karger; London: 2009-; Springer Science and Business Media LLC; S. Karger AG; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1021-7770)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Life Sciences)