Can I read Fabrication of Glycerophosphate-based Nanochitin Hydrogels for Prolonged Release Under in Vitro Physiological Conditions on EtoBox?

Fabrication of Glycerophosphate-based Nanochitin Hydrogels for Prolonged Release Under in Vitro Physiological Conditions by Liang Liu; Huazhong Ma; Juan Yu; Yimin Fan is a Materials Science article available to read on EtoBox.

What is Fabrication of Glycerophosphate-based Nanochitin Hydrogels for Prolonged Release Under in Vitro Physiological Conditions about?

Partially deacetylated nanochitin (NCh)/ glycerophosphate (GP)-based composite hydrogels were prepared for the prolonged release of microemulsions (ME) under in vitro physiological conditions. Thermo-sensitive gelation behavior not be observed for the NCh/GP composite dispersion; however, the addition of glycerophosphate also resulted in the loss of viscoelasticity due to the sodium component in the b-glycerol phosphate disodium salt pentahydrate. To prepare enhanced NCh/GP composite hydrogels, a gas phase coagulation bath was further applied to introduce physical crosslinking domains in hydrogels. The storage modulus reached approximately 1600 Pa, as 20 lL GP was composited with NCh dispersion (0.6 wt %, 2 mL), and a higher GP dosage also led to decreased mechanical strength of composite hydrogels. Because of the relatively stable inter-structure, less than 40% of ME could be released from the NCh/ GP composite hydrogel. To promote the release performance of NCh/GP-based composite hydrogels, chitosan and glycine were added. As high as 81% ME could be released from composite hydrogels at 40 °C in 50 h, as the mass ratio between NCh and chitosan was 2:1, while as high as 82% ME coul

Who reads Fabrication of Glycerophosphate-based Nanochitin Hydrogels for Prolonged Release Under in Vitro Physiological Conditions?

Author

Liang Liu; Huazhong Ma; Juan Yu; Yimin Fan

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)