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Somatic Mutations of the Mitochondrial Genome in Human Breast Cancers by Ling‐Ming Tseng; Pen‐Hui Yin; Chu‐Wen Yang; Yi‐Fang Tsai; Chih‐Yi Hsu; Chin‐Wen Chi; Hsin‐Chen Lee is a Medicine article available to read on EtoBox.

What is Somatic Mutations of the Mitochondrial Genome in Human Breast Cancers about?

## Abstract Somatic mutations in mitochondrial DNA (mtDNA) have been identified in various tumors, including breast cancer. However, their clinicopathological impact on breast cancer still remains unclear. In this study, we re‐sequenced the entire mtDNA from breast cancer samples together with paired non‐tumorous breast tissues from 58 Taiwanese patients. We identified 19 somatic mutations in the mtDNA coding region of 16 breast cancers. Out of these mutations, 12 of the 19 mutations (63%) are missense or frame‐shift mutations that have the potential to cause mitochondrial dysfunction. In combination with our previously study on the D‐loop region of mtDNA, we found that 47% (27/58) of the breast cancers harbored somatic mtDNA mutations. Among a total of 40 somatic mutations, 53% (21/40) were located in the D‐loop region of the mtDNA, 5% (2/40) were in the ribosomal RNA genes, 5% (2/40) were in the tRNA genes, and 38% (15/40) occurred in mRNA genes. The occurrence of these somatic mtDNA mutations is associated with an older onset age (≥50‐year old, __P__ = 0.039), a higher TNM stage (__P__ = 0.027), and a higher histological grade (__P__ = 0.012). Multiple logistic regression analys

Who reads Somatic Mutations of the Mitochondrial Genome in Human Breast Cancers?

Author

Ling‐Ming Tseng; Pen‐Hui Yin; Chu‐Wen Yang; Yi‐Fang Tsai; Chih‐Yi Hsu; Chin‐Wen Chi; Hsin‐Chen Lee

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2011

Language

EN

Field

Medicine (Life Sciences)