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Dynamics of insulin release and microtubular-microfilamentous system: II. Effect of vincristine by G. Devis; E. Van Obberghen; G. Somers; F. Malaisse-Lagae; L. Orci; W. J. Malaisse is a Medicine article available to read on EtoBox.

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In order to document the participation of microtubules in the dynamics of insulin release, the secretory response of the isolated perfused rat pancreas was measured after various times of exposure to vincristinc (2.10-53I). After a short exposure time (25 rain), both phases of glucose-induced insulin release were increased. After longer pretreatment (60 rain), this facilitating effect disappeared and a slight, insignificant reduction of both phases of the secretory response to glucose was observed. A still longer exposure time (120 rain) provoked a more marked and significant inhibition of the early and late phases of insulin release. The same enhancing effect after short pretreatment with vineristine was noticed when glielazide was used as the insulinotropie agent. The ultra-structural studies indicated a progressive disappearance of microtubules concomitantly with an increase in number and size of vincristine-induced paracrystalline deposits. These findings suggest that microtubules indeed participate in the dynamics of insulin release, a reduction of both phases of insulin secretion being caused by an extended disruption of the microtubular apparatus, whereas a more limited dist

Who reads Dynamics of insulin release and microtubular-microfilamentous system: II. Effect of vincristine?

Author

G. Devis; E. Van Obberghen; G. Somers; F. Malaisse-Lagae; L. Orci; W. J. Malaisse

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0012-186X)

Published

1974

Language

EN

Field

Medicine (Health Sciences)