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The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study by Patric J. Jansson; Clare L. Hawkins; David B. Lovejoy; Des R. Richardson is a Chemistry article available to read on EtoBox.

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Iron chelation therapy was initially designed to alleviate the toxic effects of excess iron evident in ironoverload diseases. However, some iron chelator-metal complexes have also gained interest due to their high redox activity and toxicological properties that have potential for cancer chemotherapy. This communication addresses the conflicting results published recently on the ability of the iron chelator, Dp44mT, to induce hydroxyl radical formation upon complexation with iron (B.B. Hasinoff and D. Patel, J Inorg. Biochem. 103 (2009Biochem. 103 ( ), 1093Biochem. 103 ( -1101)). This previous study used EPR spin-trapping to show that Dp44mT-iron complexes were not able to generate hydroxyl radicals. Here, we demonstrate the opposite by using the same technique under very similar conditions to show the Dp44mT-iron complex is indeed redox-active and induces hydroxyl radical formation. This was studied directly in an iron(II)/H 2 O 2 reaction system or using a reducing iron(III)/ascorbate system implementing several different buffers at pH 7.4. The demonstration by EPR that the Dp44mT-iron complex is redox-active confirms our previous studies using cyclic voltammetry, ascorbate oxida

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Author

Patric J. Jansson; Clare L. Hawkins; David B. Lovejoy; Des R. Richardson

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)