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Changes in Nonlinear Signal Processing in Rat Hippocampus Associated with Loss of Paired-Pulse Inhibition or Epileptogenesis by David Naylor is a Medicine article available to read on EtoBox.

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**Summary:** **Purpose:** To study acute and chronic physiological effects of perforant path stimulation using paired‐pulse and nonlinear signal analysis techniques (Wiener kernel analysis). **Methods:** Two to 3‐month‐old Wistar rats were implanted with stimulating electrodes in the perforant path and recording electrodes in the granule cell layer. Loss of paired‐pulse inhibition was produced with 2 Hz continuous and 20 Hz (10 s/min) intermittent stimulation for periods of 1–15 min (0.1 ms, 20 v pulses). Some animals received 30–60 min of stimulation, a model for status epilepticus/epileptogenesis. Responses to paired‐pulse or white noise inputs were recorded sequentially. **Results:** Loss of inhibition with brief 1–3 min of stimulation, measured by increase paired‐pulse ratio (P2/P1 ISI 40 ms) from 0.25 (±0.27) pre‐ to 1.02 (±0.18) post‐stimulation (p < 0.001), lasted 43 (±15) min. For 30–60 min of stimulation, the paired‐pulse ratios were 0.088 (±0.11), 1.59 (±0.036), 0.06 (±0.11), 0.82 (±0.22) for pre‐, immediate post‐, 1 week post‐, and 1 month poststimulation, respectively (p < 0.025). Compared to prestimulation values, Wiener kernel amplitudes for immediate, 1 week, and 1

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Author

David Naylor

Publisher

Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0013-9580)

Published

2002

Language

EN

Field

Medicine (Health Sciences)