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What is Inhibitory Amino Acid Neurotransmission and Synaptopathies about?

Inhibitory neurotransmission is critical to determine neuronal excitability, limits the magnitude and duration of firing of other CNS neurons, and shapes the activity of neuronal networks. The main inhibitory neurotransmitter in the CNS is γ‎-aminobutyric acid (GABA), which is expressed in local inhibitory neurons and in some projection neurons such as Purkinje cells and neurons in the striatum and globus pallidus. Glycine, together with GABA, is critical in inhibitory circuits of the brainstem and spinal cord. Given its importance the importance of GABAergic and glycinergic inhibition in controlling excitability in neurons and neuronal networks, impaired inhibitory transmission manifests with seizures, myoclonus, spasticity, ataxia, and pain. Several drugs used for treatment of these disorders act by increasing GABAergic inhibition.

Author

Eduardo E. Benarroch

Publisher

Oxford University Press

Published

2021

Language

EN